2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B2224R
    Thiamine disulfide (Standard) 67-16-3
    Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity.
    Thiamine disulfide (Standard)
  • HY-D0185R
    2'-Deoxyguanosine monohydrate (Standard) 312693-72-4 98%
    2'-Deoxyguanosine monohydrate (Standard) is the analytical standard of 2'-Deoxyguanosine monohydrate. This product is intended for research and analytical applications. 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer.
    2'-Deoxyguanosine monohydrate (Standard)
  • HY-D0227R
    THAM (Standard) 77-86-1 98%
    THAM (Standard) is the analytical standard of THAM. This product is intended for research and analytical applications. THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range.
    THAM (Standard)
  • HY-D0885C
    Phosphocreatine dipotassium 18838-38-5 98%
    Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway..
    Phosphocreatine dipotassium
  • HY-D0932S
    Sudan IV-d6 1014689-18-9 98%
    Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
    Sudan IV-d6
  • HY-D1686C
    Biotin-16-aminoallyluridine-5'-triphosphate 280549-77-1 98%
    Biotin-16-Aminoallyluridine-5'-Triphosphate is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-16-aminoallyluridine-5'-triphosphate
  • HY-E70243
    Tigloyl-CoA 6247-62-7 98%
    Tigloyl-CoA (Tiglyl-coenzyme A) is an intermediate product of isoleucine metabolism. Tigloyl-CoA is an inhibitor of N-acetylglutamate synthetase.
    Tigloyl-CoA
  • HY-I1060R
    L-Alloisoleucine (Standard) 1509-34-8
    L-Alloisoleucine (Standard) is the analytical standard of L-Alloisoleucine. This product is intended for research and analytical applications. L-Alloisoleucine is a stereoisomer of L-isoleucine. L-Alloisoleucine can be used in skeletal muscle research.
    L-Alloisoleucine (Standard)
  • HY-I1120R
    SGLT2-IN-1 (Standard) 864070-37-1 98%
    SGLT2-IN-1 (standard) is the analytical standard for SGLT2-IN-1. This product is used for research and analytical applications. SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter (SGLT2), with IC50 of 33 nM in CHO cells transfected with human SGLT2. SGLT2-IN-1 is selective for SGLT2 over SGLT1. SGLT2-IN-1 is an active metabolite of dapagliflozinactive metabolite of dapagliflozin.
    SGLT2-IN-1 (Standard)
  • HY-N0022R
    Isoacteoside (Standard) 61303-13-7 98%
    Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities.
    Isoacteoside (Standard)
  • HY-N0026R
    2'-Acetylacteoside (Standard) 94492-24-7
    2'-Acetylacteoside (Standard) is the analytical standard of 2'-Acetylacteoside (2'-AA) (HY-N0026). This product is intended for research and analytical applications. 2'-Acetylacteoside is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity (IC50 = 17.71 μM, Ki = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK, TRAF6, NF‑κB, NFATc1 and IKKβ, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease.
    2'-Acetylacteoside (Standard)
  • HY-N0031R
    Plantamajoside (Standard) 104777-68-6
    Plantamajoside (Standard) is the analytical standard of Plantamajoside. This product is intended for use in research and analytical applications. Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects.
    Plantamajoside (Standard)
  • HY-N0033R
    Poliumoside (Standard) 94079-81-9 98%
    Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.
    Poliumoside (Standard)
  • HY-N0075R
    (Rac)-Byakangelicin (Standard) 19573-01-4
    (Rac)-Byakangelicin (Standard) is the analytical standard of (Rac)-Byakangelicin. This product is intended for research and analytical applications. (Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC50 value of 6.2 μM.
    (Rac)-Byakangelicin (Standard)
  • HY-N0088R
    Apocynin (Standard) 498-02-2 98%
    Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
    Apocynin (Standard)
  • HY-N0122R
    5-Hydroxytryptophan (Standard) 56-69-9 98%
    5-Hydroxytryptophan (Standard) is the analytical standard of 5-Hydroxytryptophan. This product is intended for research and analytical applications. 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .
    5-Hydroxytryptophan (Standard)
  • HY-N0143R
    Phlorizin (Standard) 60-81-1 98%
    Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities.
    Phlorizin (Standard)
  • HY-N0224R
    Epigoitrin (Standard) 1072-93-1 98%
    Epigoitrin (Standard) is the analytical standard of Epigoitrin. This product is intended for research and analytical applications. Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects.
    Epigoitrin (Standard)
  • HY-N0257R
    Epimedin A (Standard) 110623-72-8
    Epimedin A (Standard) is the analytical standard of Epimedin A (HY-N0257). This product is intended for research and analytical applications. Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases.
    Epimedin A (Standard)
  • HY-N0309R
    Soyasaponin Ba (Standard) 114590-20-4
    Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba (HY-N0309). Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications.
    Soyasaponin Ba (Standard)
Cat. No. Product Name / Synonyms Application Reactivity